Preferential inhibition of the growth of virus-transformed cells in culture by rifazone-82, a new rifamycin derivative.

نویسندگان

  • M J Bissell
  • C Hatie
  • A N Tischler
  • M Calvin
چکیده

Rifazone-8(2), a new rifamycin derivative, is shown to preferentially inhibit the growth of virus-transformed chick cells in culture. Macromolecular synthesis and glucose uptake of transformed cells are also appreciably decreased in the presence of low concentrations of rifazone-8(2) where the normal cells appear unaffected. While rifazone-8(2) is shown to be a selective inhibitor of RNA-directed DNA polymerase in vitro, its action on the growth of transformed cells may involve some other mechanism.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 71 6  شماره 

صفحات  -

تاریخ انتشار 1974